Products Description
Spermine Tetrahydrochloride is a naturally occurring bioactive biogenic polyamine compound. It is widely distributed in plant tissues, microorganisms and mammalian organisms, serving as an essential active substance in biological metabolism and a vital biochemical raw material for biological scientific research, biomedicine and bioengineering fields. Adopting high-quality biologically purified raw materials instead of traditional crude chemical synthesis processes, our Spermine Tetrahydrochloride is refined through advanced procedures including hydrochloric acid modification, multi-stage recrystallization, precision filtration, low-temperature drying and sterile screening, which ensures strict raw material control and zero impurity residue throughout the production process. The core active ingredient is high-purity spermine tetrahydrochloride, with a stable purity of over 98% tested by GC, exceeding universal industrial standards. The product presents as uniform white to off-white crystalline powder with no peculiar smell and no caking, featuring extremely stable physical and chemical properties. It owns excellent water solubility, dissolving completely and rapidly in pure water at room temperature, and is slightly soluble in ethanol, suitable for various aqueous solution experiments and production systems. Supported by a comprehensive quality inspection system, we strictly control key indicators such as loss on drying, residue on ignition, heavy metals and microorganisms, delivering products with high purity and ultra-low impurities that fully meet molecular biology grade standards. With outstanding stability under sealed storage at room temperature, the product is resistant to oxidation and decomposition, with tiny batch differences and high repeatability.

Specification
|
Product Name |
Spermine Tetrahydrochloride |
|
Appearance |
White or off-white crystalline powder |
|
CAS No |
306-67-2 |
|
Purity |
98% |
|
Density |
1.01 g/mL at 20 °C |
|
Molecular formula |
C10H30Cl4N4 |
|
Molecular weight |
334.157 |
|
Flash point |
175.6ºC |
|
Exact mass |
332.106812 |
|
PSA |
76.1 |
|
Storage |
Cool and Dry Place |
|
Shelf Life |
24 months |
COA
|
Items |
Standards |
Results |
|
Appearance |
White or off-white crystalline powder |
Complies |
|
Identification |
By IR |
Complies |
|
By HPLC |
Complies |
|
|
Solubility |
Slightly soluble in water, freely soluble in ethanol and acetone, soluble in 2-propanol and insoluble in heptane |
Complies |
|
Water Content |
≤0.50% |
0.22% |
|
Residue on Ignition |
≤0.20% |
0.15% |
|
Melting Point |
120ºC~130ºC |
121.0ºC~122.0ºC |
|
Polymorphic Identity |
XRD |
Form 6 |
|
Heavy Metal |
≤20ppm |
Complies |
|
Residue Solvent |
Acetone: ≤5000ppm |
ND |
|
Toluene: ≤890ppm |
137.7ppm |
|
|
Dichloromethane: ≤600ppm |
255.1ppm |
|
|
Tetrahydrofuran: ≤720ppm |
345.4ppm |
|
|
ter-Butylmethylether: ≤5000ppm |
ND |
|
|
Related Substances |
Any Single Impurity ≤0.10% |
0.04% |
|
Total Impurities: ≤0.50% |
0.08% |
|
|
Particle Size Distribution |
D90: ≤ 45µm |
Complies |
|
Assay |
98.0~101.5% |
99.30% |
|
Reference Standard |
In-house Standard |
|
|
Conclusion |
The product complied to In-house standard. |
|
Function
Stabilize genetic structure: Possesses excellent biological activity and physicochemical regulatory capacity, effectively stabilizing DNA molecular structure, resisting damage caused by external oxidative factors, protecting the integrity of biological macromolecules within organisms and cells, and maintaining genomic stability.
Neural Care and Regulation: Can modulate neuronal-related activity in the body, regulate neuronal enzyme activity, effectively improve neuronal condition, and provide stable neuroprotective effects.
Regulate platelet activity: precisely modulate the physiological state of platelets, inhibit abnormal platelet activation, and stabilize the physiological functions of blood cells.
Regulating cellular metabolism and growth: actively participating in intracellular metabolic processes and gene expression, appropriately controlling the pace of cell proliferation and differentiation, and effectively preventing excessive cell growth.
Antioxidant and anti-stress: Effectively eliminates excess free radicals in the body, alleviates oxidative stress responses, and reduces the negative impact of oxidative damage on cells and tissues.
Optimizing chromatin conformation: capable of regulating intracellular chromatin structure, ensuring normal physiological states of chromosomes, and supporting the stable functioning of biological genetic systems.
Application
Molecular Biology Experiments: Widely applied in DNA fragment precipitation under low-salt conditions, DNA separation via pulse field gel electrophoresis, chromosome extraction, and chromatin aggregation experiments.
Biomedical Research: Suitable for the detection of various tumor tissue specimens, including tissue flow cytometry analysis, cell cycle detection, and DNA content determination of biological tissues.
Bioanalytical Detection: Used as a professional auxiliary matrix material for glycan mass spectrometry detection experiments to optimize experimental and testing conditions.
Cell Culture Industry: Served as a standard additive for various cell culture media, supporting the experimental and large-scale cultivation of different cell lines.
Advanced Scientific R&D: Routinely adopted in basic neuroscience research, biomedical intermediate synthesis, and new drug development projects.
Plant Biotechnology: Applied as a core raw material for plant cell cultivation, plant biological characteristic research and related technical development.
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