Products Description
J-147 powder (CAS: 1146963-51-0) is derived from the Salk Institute in the United States. It is a curcumin derivative developed by researchers through structural modification and optimization of curcumin. It retains the neuroprotective effect of curcumin itself, while effectively solving the problems of curcumin's rapid metabolism and low bioavailability, with significantly improved stability. Our J-147 powder is produced by lab chemical synthesis, appearing as pale yellow to off-white fine powder, with a purity of over 99% (tested by HPLC), moisture content not exceeding 0.5%, easily soluble in organic solvents such as DMSO and ethanol, but poorly soluble in water.

Specification
|
Product Name |
J-147 powder |
|
Appearance |
Pale yellow to off-white fine powder |
|
CAS |
1146963-51-0 |
|
MF |
C21H25N3O2S |
|
Assay |
99% |
|
Keywords |
J 147 |
|
Shelf Life |
24 months when properly stored |
|
Storage |
Keep in a cool, dry, dark location |
COA
|
Items |
Standards |
Results |
|
Appearance |
Pale yellow to Off white crystalline powder |
Pale yellow to off-white fine powder |
|
Identification |
By IR |
Complies |
|
By HPLC |
Complies |
|
|
Specific Rotation |
-9.0°~-14.0° |
-11.05° |
|
Loss on Drying |
≤ 1.00% |
0.04% |
|
Heavy Metals |
≤ 20ppm |
Complies |
|
Residue on Ignition |
≤ 0.10% |
0.03% |
|
Related Substances |
Any single impurity: ≤0.20% |
0.04% |
|
Total Impurities: ≤1.00% |
0.08% |
|
|
Assay |
98.0%~102.0% |
99.68% |
|
Reference Standard |
In-house Standard |
|
|
Conclusion |
The product complied to In-house standard. |
|
|
Storage |
Preserve in tight,light-resistant containers in a cool place |
|
Function
1.J-147 Powder improves Memory
2. J-147 Powder improves the brain function
3. J-147 Powder prevents and treating senile dementia
4. J-147 Powder enhances the learning ability
5. J-147 Powder increases the attention
6. J-147 Powder relieves the anxiety
Application
Neurodegenerative disease research: Applied to various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease, to carry out research on pathogenic mechanism exploration and intervention methods
Neuroprotective drug development: As a lead compound, it is used for the research, development, screening and optimization of new neuroprotective agents, anti-dementia drugs and nootropic drugs
Anti-aging related research: Used in experimental research on brain aging mechanisms, anti-aging intervention methods and longevity-related signaling pathways, providing raw material support for anti-aging research
Neurotrophic factor research: Used in the mechanism research of brain-derived neurotrophic factor (BDNF) signaling pathway regulation, neuroregeneration promotion and synaptic plasticity enhancement
Mitochondrial function research: Applied to the correlation research between mitochondrial dysfunction and neurodegenerative diseases, as well as experiments related to energy metabolism optimization and cellular aging delay
Blood-brain barrier related development: Used in the research and experimental research of new central nervous system drug delivery systems and brain-targeted drug carriers
Drug screening model construction: As a positive control, it is applied to the high-throughput screening and activity evaluation of neuroprotective active compounds
Cognitive function research: Used in experimental research on cognitive function regulation mechanisms and cognitive enhancement strategies under normal and pathological conditions
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