Products Description

Semax 80714-61-0, (Chinese names: Brain Power Peptide, Acetic Acid Brain Power Peptide) is a synthetic non-glycosylated heptapeptide, an analog of adrenocorticotropic hormone (ACTH) (4-10), commonly used as a pharmaceutical intermediate. This substance has the property of crossing the blood-brain barrier. Its core activities are significant neuroprotective, nootropic, and immunomodulatory effects. Its mechanism of action mainly includes forming a stable complex with Cu²⁺, regulating the expression of neurotrophic factors such as BDNF and NGF, protecting neurons from oxidative stress damage; inhibiting the expression of inflammation-related genes during ischemia-reperfusion, reducing neuroinflammation; enhancing choline acetyltransferase activity, improving cholinergic nerve function; and also possessing analgesic and anti-anxiety effects, with potential adjuvant effects on peptic ulcers and optic nerve diseases.

Basic Information Table

Item	Details
English Name	Semax
Chinese Name	Naoli Tai, Acetyl Naoli Tai
CAS No.	80714-61-0
EINECS No.	253-368-1
MDL No.	MFCD01631262
Molecular Formula	C₃₇H₅₁N₉O₁₀S
Molecular Weight	813.92
Amino Acid Sequence	H-Met-Glu-His-Phe-Pro-Gly-Pro-OH
Appearance	White to brownish powder, loose solid after lyophilization
Solubility	Highly soluble in water (>2mg/mL), soluble in solvents such as DMF (1mg/mL), DMSO (5mg/mL), and PBS (pH7.2, 10mg/mL)
Density	Predicted value: 1.391±0.06g/cm³
Boiling Point	Predicted value: 1335.2±65.0°C
Stability	Store at -20°C as lyophilized powder, protected from light; avoid high temperature and strong light to prevent activity loss
Storage Conditions	Store at -20°C as lyophilized powder, protected from light; avoid repeated freezing and thawing; low-temperature cold chain required for transportation

COA

ITEMS	SPECIFICATIONS	RESULTS
Appearance	White or off-white powder	Conform
Solubility	soluble in water	Conform
MS	813.9±1.0	Conform
Purity	NLT 98.0%	98.7%
Acetic acid	NMT 15.0%	4.1%
Water Content(Karl Fischer)	NMT 7.0%	4.3%
Peptide Content(N%)	NLT80%	89.9%
Conclusion	QUALIFIED.

Application

In its applications, this substance is not only a neuroprotective peptide tool, but it has also been included in the list of essential medicines in Russia for the treatment of related diseases. In other regions, it is mostly in the research stage. It can also be used as an organic intermediate to synthesize more complex peptide derivatives, optimizing activity, half-life, or targeting. Furthermore, it is widely used in in vitro cell experiments and in vivo animal models to explore its molecular mechanisms of action. Regarding safety, Semax is well-tolerated in animal studies with few adverse reactions, but strict control of dosage and route of administration is necessary, and its use must comply with the drug development and experimental regulations of different regions.